Three globally important zoonotic foodborne pathogens including Salmonella, Trichinella and Toxoplasma, were studied. Serological analysis of these pathogens was conducted on samples collected from two distinct pig production systems: antimicrobial-free, niche market type (ABF) and conventional (indoor-reared). The results from this preliminary study enabled us to understand that all the three pathogens were more commonly present in pigs that were reared in antimicrobial-free, out-door, niche-market type of environment than the commercial conventional indoor types of herds. This was found to be consistent in all the three states that were included in the current study: North Carolina, Ohio and Wisconsin.